![]() ![]() Sinusitis – first-line amoxicillin, second-line doxycycline, co-trimoxazole or cefaclor Otitis media – first-line amoxicillin, second-line erythromycin, co-trimoxazole or cefaclor Pelvic inflammatory disease – ceftriaxone in combination with doxycycline and metronidazoleĮpididymo-orchitis – ceftriaxone in combination with doxycycline Gonorrhoea – ceftriaxone in combination with azithromycin Table 1: First and second-line indications for cephalosporins Ceftriaxone is also appropriate empiric treatment for suspected meningitis (if sexually transmitted pathogens are suspected). Ceftriaxone may be usedįirst-line for some genital tract infections such as gonorrhoea, pelvic inflammatory disease (PID) and epididymo-orchitis There are few infections where cephalosporins are the antibiotics of first choice (Table 1). They are also very active against streptococci. Of cephalosporins and are active against Gram-negative organisms, including many of the significant Enterobacteriaceae. They have the widest spectrum of activity compared to other generations
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